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4 associated genes
16 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

X-linked lymphoproliferative disease

2 OMIM references -
2 associated genes
8 signs/symptoms

MALT lymphoma

X-linked lymphoproliferative disease

BIRC3	(UniProt - OMIM)		SH2D1A	(UniProt - OMIM)
FOXP1	(UniProt - OMIM)		XIAP	(UniProt - OMIM)
IGH	(UniProt)
MALT1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	BIRC3	(0.73)	XIAP

Citations in the biomedical literature:

MALT lymphoma		X-linked lymphoproliferative disease
	Synonym(s): - Extranodal marginal zone B-cell lymphoma - MALToma - Mucosa-associated lymphatic tissue lymphoma - Mucosa-associated lymphoid tissue lymphoma		Synonym(s): - Duncan disease - Purtilo syndrome - XLP

	Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease		Classification (Orphanet): - Rare genetic disease - Rare immune disease - Rare oncologic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: adulthood Average age of death: normal Type of inheritance: multigenic/multifactorial		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: - Type of inheritance: x-linked recessive

	External references: No OMIM references No MeSH references		External references: 2 OMIM references - 1 MeSH reference: D008232


COMMON SIGNS	- Lymphadenopathy / polyadenopathies

MALT lymphoma		X-linked lymphoproliferative disease
	Very frequent - Asthenia / fatigue / weakness - Epigastralgia / heartburn / gastric / duodenal ulcer / gastritis - Fever / chilling - Hematologic / blood / lymphatic cancer - Hyperhidrosis / increased sweating - Lung / pulmonary infiltrates - Nausea / vomiting / regurgitation / merycism / hyperemesis - Weight loss / loss of appetite / break in weight curve / general health alteration Frequent - Constipation Occasional - Acute abdominal pain / colic - Chronic uveitis / blepharitis / episcleritis / scleritis / conjonctivitis / keratitis - Defect / anomaly of lacrimal system - Mediastinal / hilar adenopathies - Repeat respiratory infections - Thyroid anomalies		Very frequent - T-cell deficiency / cellular immunity deficiency - X-linked recessive inheritance Frequent - Agammaglobulinemia / hypogammaglobulinemia / B-cell deficiency - Hepatomegaly / liver enlargement (excluding storage disease) - Lymphoma - Splenomegaly Occasional - Anaemia